Investigation of apoptotic activities of NOE on human ovarian cancer cells

Ovarian cancer is one of the most malignan cancers reproductive system womans. Along with other types, ovarian requires alternative agents for treatment due to limited efficiency and strong side effects classical chemotherapeutics long process. Recently, investigations are focused on intracellular targets therapy. Sphingolipid molecules, especially ceramides them reported as potent İncreased leves into cells induce apoptosis this increase can be caused by supressing ceramidases via new generation inhibitors enzymes. In study, NOE (Oleoyl ethanolamide), a ceramidase inhibitor was used cause cytotoxicity in human cells, OVCAR-3. Our results clearly showed that significantly reduced cell viability together morphological changes indicating proved flow cytometry results. proposed candicate designing anti-cancer agent after further investigations.